CELLnTEC's new estrous cycle model, CellEstrous, is the first in vitro system ever to model a complex, highly dynamic structure: the vaginal epithelium during the estrous cycle.

Diestrus

Proestrus

Estrus

Estrus/Diestrus

As seen in the series of photos, in response to cyclical hormonal levels, this in vitro system dynamically alters its structure, passing through several stages including

• thickening
• production of mucus cells
• sloughing of the cornified layer

This dynamic structural modelling is a first in vitro.

It offers a brand new approach to testing the estrous cycle, and modelling the effects of new therapeutics from both biochemical and structural perspectives simultaneously.

This in vitro system is currently available from rat. Development of a human equivalent is currently underway.