Transcription Factor Inhibitors And Related Compositions, Formulations And Methods
Institution:
Center for Childhood Cancer, The Research Institute at Nationwide Children's Hospital, Department of Pediatrics, College of Medicine, Columbus
Country:
USA
Year:
2011
Journal Name:
United States Patent Application 20110212911
The present invention provides small molecules useful to affect cancer cells, along with related methods. The present compounds, formulations, kits and methods are useful for a variety of research, diagnostic and therapeutic purposes. STAT3 inhibitors, particularly LLL12, are disclosed. The STAT3 inhibitors are useful to treat breast cancer in general and breast cancer initiating cells in particular.
Tissue Type:
Pancreatic Duct
Tissue Info:
Immortalized human pancreatic duct epithelial (HPDE) cells
Species:
Human
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